Inactivation of cerebral glutamine synthetase by dl-methionine-dl-sulfoximine
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چکیده
منابع مشابه
The inhibition of cerebral glutamine synthetase by structural analogs of the convulsant dl-methionine sulfoximine.
GLUTAMINE synthetase [L-glutamate-ammonia ligase (ADP)] (EC 6.3.1.2) of rat cerebral cortex may be readily inhibited by the convulsant agent dl-methionine-di-sulfoximine (MSO), both in vitro and in vivo. 1, 8 Although in vitro this inhibition is readily reversible by excess substrate, L-glutamate, the inhibition in vivo appears to reflect a nonreversible interaction of the convulsant drug with ...
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Both the adenylylated and unadenylylated forms of Escherichia coli glutamine synthetase catalyze the formation of pyrrolidone carboxylate from glutamate in the presence of ATP and divalent metal ions (Mg++ or Mn++) and in the absence of ammonia. The unadenylylated enzyme catalyzes this reaction more rapidly with Mg++ than with Mn++, while the adenylylated enzyme catalyzes it more rapidly with M...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Enzymology
سال: 1967
ISSN: 0005-2744
DOI: 10.1016/0005-2744(67)90172-6